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Sympathomimetic amines should be used judiciously in patients with hypertension, diabetes mellitus, ischemic heart disease, increased intraocular pressure, hyperthyroidism, or prostatic hypertrophy.
Central nervous system stimulation with convulsions or cardiovascular collapse with accompanying hypotension may be produced by sympathomimetic amines.
Acute generalized exanthematous pustulosis (AGEP), a form of severe skin reaction, may occur with pseudoephedrine-containing products in isolated cases. If signs and symptoms such as fever, erythema, or small (generalized) pustules are observed, patients should discontinue to use the drug and consult their physician.
Patients with hepatic insufficiency should be given a lower initial dose (one tablet every other day) because of reduced clearance of loratadine.
Patients who have a history of difficulty in swallowing tablets or who have known gastrointestinal narrowing or abnormal esophageal peristalsis should not use this product.
Drug Abuse and Dependence: No data are available to indicate that abuse or dependency occurs with loratadine.
Like other CNS stimulants, pseudoephedrine sulfate has a potential for abuse, and increased doses may ultimately produce toxicity. Depression may follow rapid withdrawal.
Use in Children: Safety and efficacy of CLARINASE 24Hr Tablets in children younger than 12 years of age have not yet been established.
